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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: NPR1 All Species: 30.61
Human Site: S538 Identified Species: 61.21
UniProt: P16066 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P16066 NP_000897.3 1061 118919 S538 L T L S G R G S N Y G S L L T
Chimpanzee Pan troglodytes XP_001168194 1047 116964 S522 L T L S L R G S S Y G S L M T
Rhesus Macaque Macaca mulatta XP_001085221 1047 116990 S522 L T L S L R G S S Y G S L M T
Dog Lupus familis XP_547577 1060 118154 S537 L T L S G R G S N Y G S L L T
Cat Felis silvestris
Mouse Mus musculus P18293 1057 119091 S534 L T L S G R G S N Y G S L L T
Rat Rattus norvegicus P18910 1057 118933 S534 L T L S G R G S N Y G S L L T
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001517544 743 84256 N273 H M R D V Q F N H L T R F I G
Chicken Gallus gallus
Frog Xenopus laevis NP_001083703 1056 120483 S532 L T L S L R G S N Y G S L I T
Zebra Danio Brachydanio rerio NP_001038402 1067 121798 S544 L T I S L R G S N Y G S L L T
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q07553 1163 130896 C530 N K N I F Q I C R Q S I L V V
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q09435 1137 128085 I563 S L Q S A P S I S T G H S G V
Sea Urchin Strong. purpuratus P16065 1125 126238 M571 F S M K N M V M S A I S V I S
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 61.2 61.2 91.6 N.A. 90.8 90.8 N.A. 48.5 N.A. 66.1 62.7 N.A. 31.5 N.A. 29.8 35.1
Protein Similarity: 100 73.8 73.8 95 N.A. 94.2 94.2 N.A. 58.6 N.A. 78.7 77.5 N.A. 47.8 N.A. 49 50.8
P-Site Identity: 100 80 80 100 N.A. 100 100 N.A. 0 N.A. 86.6 86.6 N.A. 6.6 N.A. 13.3 6.6
P-Site Similarity: 100 93.3 93.3 100 N.A. 100 100 N.A. 26.6 N.A. 93.3 93.3 N.A. 20 N.A. 20 46.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 9 0 0 0 0 9 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 9 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 9 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 9 0 0 0 9 0 9 0 0 0 0 0 9 0 0 % F
% Gly: 0 0 0 0 34 0 67 0 0 0 75 0 0 9 9 % G
% His: 9 0 0 0 0 0 0 0 9 0 0 9 0 0 0 % H
% Ile: 0 0 9 9 0 0 9 9 0 0 9 9 0 25 0 % I
% Lys: 0 9 0 9 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 67 9 59 0 34 0 0 0 0 9 0 0 75 42 0 % L
% Met: 0 9 9 0 0 9 0 9 0 0 0 0 0 17 0 % M
% Asn: 9 0 9 0 9 0 0 9 50 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 9 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 9 0 0 17 0 0 0 9 0 0 0 0 0 % Q
% Arg: 0 0 9 0 0 67 0 0 9 0 0 9 0 0 0 % R
% Ser: 9 9 0 75 0 0 9 67 34 0 9 75 9 0 9 % S
% Thr: 0 67 0 0 0 0 0 0 0 9 9 0 0 0 67 % T
% Val: 0 0 0 0 9 0 9 0 0 0 0 0 9 9 17 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 67 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _